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Transient cognitive and behavioral stabilization of patients with Alzheimer's disease (AD) is the main goal of long-term acetylcholinesterase inhibitor (AChEI) therapy, but response to treatment is variable and, indeed, only some of the patients are stabilized. This is usually assessed by means of clinical and neuropsychologic scales, whereas functional neuroimaging could allow objective evaluation of the topographic correlates of the effect of therapy on brain functioning. The aim of this study was to evaluate brain perfusion changes by SPECT in AD patients during chronic AChEI therapy in relation to their cognitive evolution.

More information

Journal article


J Nucl Med

Publication Date





983 - 990


Aged, Alzheimer Disease, Brain, Carbamates, Case-Control Studies, Cerebrovascular Circulation, Cholinesterase Inhibitors, Cognition, Female, Follow-Up Studies, Humans, Indans, Male, Phenylcarbamates, Piperidines, Radiopharmaceuticals, Technetium Tc 99m Exametazime, Time Factors, Tomography, Emission-Computed, Single-Photon