Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of illness and treatment suitability. In this pilot, we examined nine patients with amnestic mild cognitive impairment (MCI) and 10 age and education matched healthy volunteers with high resolution SPECT and the nicotinic receptor ligand 5-(123)I-A-85380. Uptake data were analysed using voxel-based techniques for group comparisons and regression analyses with cognitive impairment as covariates. MCI patients had discrete reductions in uptake in medial temporal cortex. Correlations with cognitive impairment were found in left temporo-parietal areas (Addenbrooke's Cognitive Examination) and bilateral temporo-limbic areas (Rey Auditory Verbal Learning Test), and right parahippocampal gyrus (Rey Complex Figure Test) within the patient group. In vivo nicotinic receptor binding appears to be sensitive to brain changes in MCI. Larger scale explorations of patients undergoing treatment will be necessary to evaluate its use in predicting or monitoring treatment response.

More information
Type

Journal article

Journal

Neurobiol Aging

Publication Date

11/2010

Volume

31

Pages

1885 - 1893

Keywords

Aged, Aged, 80 and over, Azetidines, Brain, Case-Control Studies, Cognition Disorders, Female, Humans, Iodine Radioisotopes, Limbic System, Male, Matched-Pair Analysis, Neuropsychological Tests, Parahippocampal Gyrus, Parietal Lobe, Pilot Projects, Pyridines, Receptors, Nicotinic, Reference Values, Temporal Lobe, Tomography, Emission-Computed, Single-Photon