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Patients with schizophrenia differ from controls in several measures of brain structure and function, but it is uncertain how these relate to clinical features of the illness. We dichotomised patient groups by treatment response to test the hypothesis that treatment-resistant patients exhibit more marked biological abnormalities than treatment-responsive patients.

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Journal article


Br J Psychiatry

Publication Date





202 - 210


Activities of Daily Living, Adult, Antipsychotic Agents, Brain, Chronic Disease, Delirium, Dementia, Amnestic, Cognitive Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Mental Recall, Middle Aged, Neuropsychological Tests, Prognosis, Regional Blood Flow, Schizophrenia, Schizophrenic Psychology, Social Adjustment, Tomography, Emission-Computed, Single-Photon, Treatment Outcome