Treatment-resistant depression (TRD) is relatively common but its neurobiological basis is poorly understood. Fronto-striatal structural brain changes have been reported in patients with depression but their association with treatment resistance and chronicity has not been established.

More information
Type

Journal article

Journal

Br J Psychiatry

Publication Date

05/2002

Volume

180

Pages

434 - 440

Keywords

Adult, Aged, Atrophy, Brain, Brain Mapping, Chronic Disease, Depressive Disorder, Drug Resistance, Electroconvulsive Therapy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales