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A new review of previous studies into the long-term effects of childhood sexual abuse has suggested that earlier mental health support for victims would reduce the chances of victims developing psychiatric conditions and substance misuse later in life.
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Modifying Dementia Risk
Cognitive Dementia Depression Epidemiology Risk factors
Modifiable risk factors for dementia include those factors that can be altered or changed in some way (modified), usually for the better. The Lancet 2020 commission (Livingston et al., 2020) advocated that there are 12 risk factors which can be potentially modified to prevent or slow the progression of dementia. These are less education, hypertension, obesity, alcohol, traumatic brain injury (TBI), hearing loss, smoking, depression, physical inactivity, social isolation, diabetes and air pollution.
Early Adversity & Brain Health
Alzheimer's Brain function Cognitive Dementia Depression Mood
Blossom Early Adversity & Brain Health Programme is dedicated to investigating the effects of early life adversity on later life brain health, including mental health, cognition and dementia.
Heart and Brain Ageing Group
Alzheimer's Brain function Brain imaging Cognitive Dementia Magnetic Resonance Imaging (MRI) Medical co-morbidity Medicine
Nearly a third of dementia cases can be prevented by modifying our lifestyle, in particular our cardiovascular health. While we know that “what’s good for the heart is good for the brain”, we still don’t entirely know why. Our group investigates this heart-brain link in detail, by studying how the health of our heart and large blood vessels affect the brain and memory as we grow older.
Translational Neuroscience & Dementia Research
Alzheimer's Case registers Clinical trial Dementia Dopamine Neuroscience Parkinson's
The Translational Neuroscience and Dementia Research Group undertake translational research ranging from mechanisms to drug development, and from discovery to qualification of molecular and imaging biomarkers in both Alzheimer’s disease and Parkinson’s disease and in related dementia disorders. The group, led by Professor Noel Buckley, comprises molecular and cellular biology scientists, computational biologists and informaticians working with molecular, clinical and imaging datasets. We have three main areas of activity, all aiming towards secondary prevention of dementia. By understanding disease mechanisms we seek potential therapeutics; through discovery of biomarkers we hope to enable preventative trials, and with informatics we utilise large biological and clinical datasets in the support of translational neuroscience.
Translational Neuroimaging
Alzheimer's Brain Brain function Brain imaging Clinical trial Cognitive models Cohorts Dementia Empirical Functional imaging Genetics Magnetic Resonance Imaging (MRI) Medical imaging Neuroimaging Neurology Neuroscience Parkinson's Risk factors Whitehall Study
Neuroimaging provides a window into the living brain, and is an increasingly vital experimental medicine tool for neuro-psychiatric disease. With a particular focus on early and pre-clinical disease, we explore how the brain changes before symptoms take hold.