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<jats:title>Summary</jats:title><jats:p>We studied the course of major mood disorders in the offspring of parents with well-characterised bipolar disorder prospectively for up to 15 years. All consenting offspring were assessed annually or anytime symptomatic. The participants began to develop major mood episodes in adolescence and not before. The index major mood episode was almost always depressive, as were the first few recurrences. Onsets and recurrences continued throughout the observation period into adulthood. We did not find evidence of pre-pubertal mania. In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder.</jats:p>

Original publication

DOI

10.1192/bjp.bp.108.062810

Type

Journal article

Journal

British Journal of Psychiatry

Publisher

Royal College of Psychiatrists

Publication Date

11/2009

Volume

195

Pages

457 - 458