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We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. "PSQI # 1 Subjective sleep quality" and "PSQI #5 Sleep disturbances" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with "PSQI #5 Sleep disturbances" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

Original publication

DOI

10.1093/cercor/bhaa332

Type

Journal article

Journal

Cereb Cortex

Publication Date

05/03/2021

Volume

31

Pages

1953 - 1969

Keywords

aging, atrophy, cortex, sleep, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cerebral Cortical Thinning, Cognitive Dysfunction, Female, Humans, Longevity, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Self Report, Sleep Quality, Sleep Wake Disorders, Young Adult