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In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

Original publication

DOI

10.1192/bjp.2020.163

Type

Journal article

Journal

Br J Psychiatry

Publication Date

23/10/2020

Pages

1 - 4

Keywords

E/I balance, GABA, autism spectrum disorders, schizophrenia, transdiagnostic