Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research.
Journal article
J Psychopharmacol
12/2020
34
1461 - 1465
Fluoxetine, adolescent depression, resting-state functional connectivity, Adolescent, Cerebral Cortex, Connectome, Default Mode Network, Depressive Disorder, Major, Female, Fluoxetine, Humans, Magnetic Resonance Imaging, Male, Selective Serotonin Reuptake Inhibitors