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Antidepressant medications generally are considered to have a delayed onset of action; however, recent evidence is beginning to challenge this conventional wisdom. Meta-analysis of placebo-controlled, randomized trials reveals that patients with depression are more likely to experience a clinically significant response with antidepressants than with placebo by the end of the first week of treatment. About one third of the total treatment benefit over 6 weeks is evident by the end of the first week. Early response to antidepressants is not necessarily a placebo response.

Original publication

DOI

10.1007/s11920-007-0064-0

Type

Journal article

Journal

Curr Psychiatry Rep

Publication Date

12/2007

Volume

9

Pages

475 - 479

Keywords

Antidepressive Agents, Depressive Disorder, Major, Humans, Time Factors