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BACKGROUND: Previous studies have reached conflicting conclusions about the role of atopy as a risk factor for COPD. In part, this is attributable to variation in the definitions of airflow limitation and the treatment of people with asthma. OBJECTIVE: To establish whether there is any independent association between atopy and post-bronchodilator airflow limitation in the general population aged 40 years and over. METHODS: A cross-sectional survey was conducted in a general population sample of 2415 people aged 40 years and over in Australia. A history of ever being diagnosed with asthma was elicited by questionnaire. Atopy was defined as any skin prick test weal to common aeroallergens ≥4 mm. Airflow limitation was defined as post-bronchodilator spirometric (FEV1 /FVC) ratio

Original publication




Journal article


Clin Exp Allergy

Publication Date





1625 - 1630


COPD, airflow limitation, allergic sensitization, asthma, atopy, epidemiology, population health, Adult, Aged, Female, Humans, Hypersensitivity, Immediate, Immunization, Male, Middle Aged, Prevalence, Public Health Surveillance, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests, Risk Factors, Socioeconomic Factors, Spirometry, Surveys and Questionnaires