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Administration of the non-selective 5-HT receptor antagonist metergoline (0.5 mg/kg) to male rats attenuated the prolactin response to the 5-HT releasing agent d-fenfluramine (7.5 mg/kg) but not to the dopamine receptor antagonist haloperidol (1.5 mg/kg). In contrast, in healthy male volunteers, pretreatment with metergoline (4 mg orally) abolished the prolactin response to intravenous haloperidol (5 micrograms/kg). The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1991

Volume

105

Pages

129 - 131

Keywords

Adolescent, Adult, Animals, Brain Chemistry, Fenfluramine, Haloperidol, Humans, Male, Metergoline, Prolactin, Rats, Rats, Inbred Strains, Serotonin, Serotonin Antagonists