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Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.


Journal article



Publication Date





1484 - 1487


Aged, Alzheimer Disease, Analysis of Variance, Cerebrovascular Circulation, Drug Evaluation, Female, Glycopyrrolate, Humans, Infusions, Intravenous, Male, Middle Aged, Organotechnetium Compounds, Oximes, Parasympathetic Nervous System, Parietal Lobe, Physostigmine, Technetium Tc 99m Exametazime, Temporal Lobe, Tomography, Emission-Computed, Single-Photon