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We studied the effect of the 5-HT1A receptor antagonist, pindolol, on the prolactin (PRL) response to the 5-HT releasing agent, d-fenfluramine (d-FEN), in ten healthy male volunteers. Pindolol pretreatment lowered baseline PRL levels but, when this effect was taken into account, did not significantly attenuate the PRL response to d-FEN. Within the limitations that attend the use of pindolol as a 5-HT1A receptor antagonist, the data suggest that although 5-HT1A receptors may play a role in the tonic release of PRL, they are not involved in the release of PRL produced by d-FEN. We propose that the PRL response to d-FEN may involve selective activation of postsynaptic 5-HT2 receptors.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

04/1995

Volume

118

Pages

471 - 474

Keywords

Adult, Dose-Response Relationship, Drug, Double-Blind Method, Fenfluramine, Humans, Male, Middle Aged, Pindolol, Prolactin, Receptors, Serotonin, Serotonin Antagonists