Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The selective NK-3 tachykinin receptor agonist senktide elicited yawning, chewing mouth movements and sexual arousal following subcutaneous administration (0.1-1.0 mg/kg) in the rat. These responses were not significantly affected by the dopamine antagonist haloperidol (0.03 mg/kg) or by 6-hydroxydopamine lesions of the nigrostriatal projection. In contrast, the behaviours were markedly attenuated by the peripheral and central muscarinic antagonist scopolamine (1 mg/kg), but not by the peripheral muscarinic antagonist N-methylscopolamine (1 mg/kg). These findings suggest that stimulation of NK-3 receptors produces yawning, chewing and sexual arousal by directly activating central cholinergic neurons.


Journal article


Psychopharmacology (Berl)

Publication Date





502 - 506


Animals, Brain Chemistry, Dose-Response Relationship, Drug, Haloperidol, Hydroxydopamines, Injections, Subcutaneous, Male, Oxidopamine, Parasympathetic Nervous System, Peptide Fragments, Rats, Rats, Inbred Strains, Receptors, Neurotransmitter, Receptors, Tachykinin, Scopolamine Hydrobromide, Stereotyped Behavior, Substance P, Yawning