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The selective NK-3 tachykinin receptor agonist senktide elicited yawning, chewing mouth movements and sexual arousal following subcutaneous administration (0.1-1.0 mg/kg) in the rat. These responses were not significantly affected by the dopamine antagonist haloperidol (0.03 mg/kg) or by 6-hydroxydopamine lesions of the nigrostriatal projection. In contrast, the behaviours were markedly attenuated by the peripheral and central muscarinic antagonist scopolamine (1 mg/kg), but not by the peripheral muscarinic antagonist N-methylscopolamine (1 mg/kg). These findings suggest that stimulation of NK-3 receptors produces yawning, chewing and sexual arousal by directly activating central cholinergic neurons.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1988

Volume

95

Pages

502 - 506

Keywords

Animals, Brain Chemistry, Dose-Response Relationship, Drug, Haloperidol, Hydroxydopamines, Injections, Subcutaneous, Male, Oxidopamine, Parasympathetic Nervous System, Peptide Fragments, Rats, Rats, Inbred Strains, Receptors, Neurotransmitter, Receptors, Tachykinin, Scopolamine Hydrobromide, Stereotyped Behavior, Substance P, Yawning