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The behavioural effects of the selective NK-3 tachykinin receptor agonist senktide were studied following intracisternal and subcutaneous administration in rodents. Behavioural manifestations of 5-hydroxytryptaminergic stimulation, including head twitches (mice), wet dog shakes (rats), forepaw treading, flat body posture, hindlimb splaying and Straub tail, were seen following the intracisternal (0.01-1.2 nmol) or subcutaneous (0.1-2.4 mumol kg-1) administration of senktide in both species. We conclude that stimulation of NK-3 receptors stimulates 5-hydroxytryptaminergic pathways in rodent brain, and that senktide may cross the blood-brain barrier in biologically significant amounts.

Type

Journal article

Journal

Br J Pharmacol

Publication Date

06/1988

Volume

94

Pages

285 - 287

Keywords

Animals, Behavior, Animal, Female, Injections, Subcutaneous, Male, Mice, Mice, Inbred Strains, Peptide Fragments, Rats, Rats, Inbred Strains, Receptors, Neurotransmitter, Receptors, Tachykinin, Serotonin, Substance P