Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 degrees C) water bath. L-365,260 at doses of 100 ng/kg to 100 micrograms/kg significantly elevated tail withdrawal latencies throughout a 2 h test period. These data provide the first evidence that blockade of CCK-B receptors induces analgesia in primates.

Type

Journal article

Journal

Brain Res

Publication Date

26/11/1990

Volume

534

Pages

287 - 290

Keywords

Analgesia, Animals, Benzodiazepinones, Cholecystokinin, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Male, Pain, Phenylurea Compounds, Receptors, Cholecystokinin, Saimiri, Time Factors