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Whole genome transcriptomic analyses have identified large numbers of dynamically expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose functions are, as yet, largely unknown. Here we summarize the growing evidence that lncRNAs, like mRNAs, can be trafficked to and function in a wide variety of subcellular locations. Investigation of the subcellular distribution of lncRNAs has the potential to greatly expand our knowledge not only of the function of lncRNAs but also of cell biology by identifying previously unknown subcellular structures and novel constituents of known cellular organelles. © 2011 Elsevier Ltd.

Original publication

DOI

10.1016/j.semcdb.2011.01.001

Type

Journal article

Journal

Seminars in Cell and Developmental Biology

Publication Date

01/01/2011

Volume

22

Pages

366 - 376