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Spine motility analysis has become the mainstay for investigating synaptic plasticity but is limited in its versatility requiring complex, non automatized instrumentations. We describe an entropy-based method for determining the spatial distribution of dendritic spines that allows successful estimation of spine motility from still images. This method has the potential to extend the applicability of spine motility analysis to ex vivo preparations.

Original publication

DOI

10.1038/srep14622

Type

Journal article

Journal

Sci Rep

Publication Date

30/09/2015

Volume

5

Keywords

Algorithms, Animals, Dendrites, Dendritic Spines, Mice, Mice, Knockout, Models, Biological, Neuronal Plasticity, Neurons