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The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

Original publication

DOI

10.1016/j.neurobiolaging.2015.10.028

Type

Journal article

Journal

Neurobiol Aging

Publication Date

02/2016

Volume

38

Pages

214.e7 - 214.10

Keywords

Alzheimer's disease, Dementia with Lewy bodies, Genetic correlation, Parkinson's disease, Alzheimer Disease, Apolipoproteins E, Cohort Studies, Genetic Loci, Genome-Wide Association Study, Humans, Lewy Body Disease, Parkinson Disease