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Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.


Journal article


Semin Immunol

Publication Date





247 - 253


Antigens, Antigens, Differentiation, B-Lymphocytes, Cell Compartmentation, Cell Line, Endocytosis, Endosomes, HLA-D Antigens, Humans, Immunoglobulin G, Receptors, Fc, Receptors, IgG