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AIMS: To determine areas of atrophy in patients that are associated with caregiver burden. METHODS: We measured caregiver burden, dementia and neuropsychiatric scores in 22 patients with corticobasal syndrome (CBS) and 25 with frontotemporal dementia (FTD), and in 14 healthy controls. We used voxel-based morphometry to correlate caregiver burden with gray matter loss. RESULTS: Increased dementia and behavioral disturbances contributed to higher burden scores in CBS patients, while behavioral disturbances alone significantly affected burden scores in frontal-variant FTD (FTD-fv) patients. In CBS patients, caregiver burden scores correlated with atrophy in left inferior and middle temporal gyri. CONCLUSIONS: Caregivers of FTD-fv patients had significantly higher burden scores than caregivers of CBS patients. Damage to areas important in semantic knowledge appears critical in increased burden for CBS caregivers.

Original publication




Journal article


Dement Geriatr Cogn Disord

Publication Date





467 - 474


Aged, Basal Ganglia Diseases, Behavior, Caregivers, Cost of Illness, Dementia, Female, Humans, Knowledge, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Stress, Psychological