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BACKGROUND: Falling participation by young women in cervical screening has been observed at a time that has seen an increase in the incidence of cervical cancer in the UK in women aged  90%. CONCLUSION: Women receiving their initial screening invitation frequently delay taking up the offer and the net impact of interventions was small. Timed appointments and SSKs sent to non-attenders at 6 months are likely to be a cost-effective means of increasing uptake and should be considered further. HPV vaccination in the catch-up programme was associated with an increased uptake of cervical screening. Future work should focus on optimising self-sampling in terms of age range, timing of offer for non-attenders and use of urine testing instead of vaginal samples. TRIAL REGISTRATION: Current Controlled Trials ISRCTN52303479. FUNDING: This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 20, No. 68. See the NIHR Journals Library website for further project information.

Original publication




Journal article


Health Technol Assess

Publication Date





1 - 138


Age Factors, Appointments and Schedules, Choice Behavior, Cost-Benefit Analysis, Early Detection of Cancer, Female, General Practice, Humans, Papillomavirus Vaccines, Patient Acceptance of Health Care, Patient Navigation, Patient Participation, Quality-Adjusted Life Years, Scotland, State Medicine, Uterine Cervical Neoplasms, Young Adult