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History teaches that sterile insect technique (SIT) is a feasible strategy for mosquito population suppression. Female killing (FK) technologies developed later theoretically had greater potential than SIT, but depended upon chromosomal translocations. Unfortunately these were genetically unstable. New transgenic strategies have been misinterpreted as a replacement for SIT. Instead these strategies provide a means to revisit FK. Conditional lethal mutations inserted into mosquito genomes allow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipulation of germline-specific gene expression. A recent Aedes aegypti case study demonstrates the viability of one of these new transgenic strategies.

Original publication




Journal article


Trends Parasitol

Publication Date





362 - 370


Alleles, Animals, Animals, Genetically Modified, Culicidae, Female, Gene Transfer Techniques, Genes, Dominant, Genes, Lethal, Genotype, Infertility, Male, Mosquito Control, Mutagenesis, Insertional, Translocation, Genetic