Image-guided injection and noninvasive monitoring of tissue regeneration in the stroke-damaged brain
Chou CH., Nicholls F., Modo M.
© Springer-Verlag Wien 2013. Cell therapy is gradually emerging from the bench to the bedside. To ensure an efficient translation, it will be important to define the conditions under which implanted/injected cells can be efficacious. Noninvasive imaging is required to select appropriate patients but is also essential for surgical planning as to where cells need to be implanted. With the emergence of cells being combined with biomaterials for in situ tissue engineering, it become important to non-invasively visualize not only the individual components, but also the complex process of tissue formation. We here review these various issues and discuss various strategies that can be pursued to provide an image-guidance for cell therapy as well as the development of means to noninvasively monitor tissue engineering in the stroke-damaged brain.