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The most recent genome-wide association study in amyotrophic lateral sclerosis (ALS) demonstrates a disproportionate contribution from low-frequency variants to genetic susceptibility to disease. We have therefore begun Project MinE, an international collaboration that seeks to analyze whole-genome sequence data of at least 15 000 ALS patients and 7500 controls. Here, we report on the design of Project MinE and pilot analyses of successfully sequenced 1169 ALS patients and 608 controls drawn from the Netherlands. As has become characteristic of sequencing studies, we find an abundance of rare genetic variation (minor allele frequency 

Original publication

DOI

10.1038/s41431-018-0177-4

Type

Journal article

Journal

Eur J Hum Genet

Publication Date

10/2018

Volume

26

Pages

1537 - 1546

Keywords

Amyotrophic Lateral Sclerosis, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Genome-Wide Association Study, Humans, Male, Netherlands, Polymorphism, Single Nucleotide, Whole Genome Sequencing