Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.
Gillespie RJ., Cliffe IA., Dawson CE., Dourish CT., Gaur S., Jordan AM., Knight AR., Lerpiniere J., Misra A., Pratt RM., Roffey J., Stratton GC., Upton R., Weiss SM., Williamson DS.
A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's disease.