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A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's disease.

Original publication

DOI

10.1016/j.bmcl.2008.03.072

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

01/05/2008

Volume

18

Pages

2924 - 2929

Keywords

Adenosine A1 Receptor Antagonists, Adenosine A2 Receptor Antagonists, Antiparkinson Agents, Drug Design, Humans, Models, Chemical, Parkinsonian Disorders, Purines, Pyrazoles, Pyrimidines, Stereoisomerism, Structure-Activity Relationship