Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for the compounds at 5-HT(2) receptor subtypes are reported. The analogue which showed the highest 5-HT(2C) binding affinity (27, 1.6nM) was found to be successful in reducing food intake in rats.

Original publication

DOI

10.1016/j.bmcl.2005.10.029

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

02/2006

Volume

16

Pages

677 - 680

Keywords

Animals, Anti-Obesity Agents, Disease Models, Animal, Eating, Isoquinolines, Pyrroles, Quinolines, Radioligand Assay, Rats, Serotonin 5-HT2 Receptor Agonists, Serotonin Receptor Agonists