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A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for the compounds at 5-HT(2) receptor subtypes are reported. The analogue which showed the highest 5-HT(2C) binding affinity (27, 1.6nM) was found to be successful in reducing food intake in rats.

Original publication




Journal article


Bioorg Med Chem Lett

Publication Date





677 - 680


Animals, Anti-Obesity Agents, Disease Models, Animal, Eating, Isoquinolines, Pyrroles, Quinolines, Radioligand Assay, Rats, Serotonin 5-HT2 Receptor Agonists, Serotonin Receptor Agonists