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Activation of 5-HT(1B) receptors is thought to play an important role in the inhibitory influence of serotonin on feeding behaviour and body weight in mammals. Earlier studies have shown that 5-HT(1B)-knockout (KO) mice eat more and are heavier than wild-type (WT) controls and that the selective 5-HT(1B) receptor agonist CP-94,253 reduces food intake in food-deprived mice. Here we characterize the behavioural effects of both CP-94,253 and the selective 5-HT(1B) receptor antagonist SB224289 on feeding and other behaviours within the behavioural satiety sequence, and also report a c-fos mapping study using CP-94,253. CP-94,253 produced a dose-dependent suppression of food intake with a profile consistent with a selective effect on feeding behaviour. These effects were absent or reduced in 5-HT(1B)-KO mice and in WT mice pretreated with SB224289. SB224289 administered alone enhanced food intake consistent with impaired satiation; a similar effect was apparent in 5-HT(1B)-KO mice compared to WT. CP-94,253 induced c-fos in a range of structures previously implicated in the expression of feeding behaviour. These results suggest that the activation of 5-HT(1B) receptors is an important component of endogenous satiation mechanisms in the mouse.

Original publication

DOI

10.1111/j.0953-816X.2004.03406.x

Type

Journal article

Journal

Eur J Neurosci

Publication Date

06/2004

Volume

19

Pages

3017 - 3025

Keywords

Animals, Behavior, Animal, Body Weight, Brain, Dose-Response Relationship, Drug, Drug Interactions, Eating, Feeding Behavior, Gene Expression Regulation, Immunohistochemistry, Mice, Mice, Knockout, Oxadiazoles, Piperazines, Piperidones, Proto-Oncogene Proteins c-fos, Pyridines, Receptor, Serotonin, 5-HT1B, Serotonin Antagonists, Serotonin Receptor Agonists, Spiro Compounds, Time Factors