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A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds at 5-HT(2) receptor subtypes are reported. A number of compounds were found to reduce food intake in rats after oral administration.

Original publication

DOI

10.1016/j.bmcl.2003.05.001

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

03/05/2004

Volume

14

Pages

2367 - 2370

Keywords

Animals, Anti-Obesity Agents, Indoles, Rats, Serotonin 5-HT2 Receptor Agonists, Serotonin Receptor Agonists