Indoline derivatives as 5-HT(2C) receptor agonists.
Bentley JM., Adams DR., Bebbington D., Benwell KR., Bickerdike MJ., Davidson JEP., Dawson CE., Dourish CT., Duncton MAJ., Gaur S., George AR., Giles PR., Hamlyn RJ., Kennett GA., Knight AR., Malcolm CS., Mansell HL., Misra A., Monck NJT., Pratt RM., Quirk K., Roffey JRA., Vickers SP., Cliffe IA.
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds at 5-HT(2) receptor subtypes are reported. A number of compounds were found to reduce food intake in rats after oral administration.