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The role of AT1 and AT2 receptors in mediating the drinking response induced by angiotensin II in the rat was examined. Angiotensin II (0.1-1.0 mg/kg s.c.) caused a dose-dependent increase in drinking in water-replete rats. The angiotensin Il-induced drinking response was dose dependently blocked by the selective AT1 receptor antagonist DuP 753 (1-30 mg/kg s.c.). In contrast, the selective AT2 receptor antagonist WL 19 failed to block angiotensin II-induced drinking up to doses of 100 mg/kg s.c. and significantly enhanced the response at 3 and 100 mg/kg. These data suggest that drinking induced by angiotensin II is mediated by AT1 receptors and that AT2 receptor activation may inhibit the drinking response.

Type

Journal article

Journal

Eur J Pharmacol

Publication Date

28/01/1992

Volume

211

Pages

113 - 116

Keywords

Angiotensin II, Angiotensin Receptor Antagonists, Animals, Biphenyl Compounds, Dose-Response Relationship, Drug, Drinking, Imidazoles, Injections, Subcutaneous, Losartan, Male, Pyridines, Rats, Rats, Inbred Strains, Tetrazoles