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The effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined. Gepirone dose-dependently increased feeding 2 and 4 h after injection, the magnitude of the response being larger than previously observed with any other 5-HT1A receptor ligand. Previous studies have suggested that buspirone and ipsapirone can block some of the behavioural effects of 8-OH-DPAT. However, gepirone, buspirone and ipsapirone did not inhibit feeding induced by 8-OH-DPAT. These results indicate that gepirone is a very efficacious appetite stimulant in rats and suggest that gepirone, buspirone and ipsapirone act as 5-HT autoreceptor agonists in the feeding model.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1987

Volume

93

Pages

349 - 352

Keywords

8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Anti-Anxiety Agents, Buspirone, Eating, Hyperphagia, Male, Naphthalenes, Pyrimidines, Rats, Rats, Inbred Strains, Receptors, Serotonin, Tetrahydronaphthalenes