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The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked by the 5-HT1C antagonists mesulergine and metergoline but not by spiperone, ketanserin, or (-)-pindolol. The results suggest that MK-212 activates the 5-HT1C receptor subtype to increase ACTH.


Journal article


Neurosci Lett

Publication Date





174 - 176


Adrenocorticotropic Hormone, Animals, Antiparkinson Agents, Ergolines, Ketanserin, Male, Metergoline, Pindolol, Piperazines, Pyrazines, Rats, Rats, Inbred Strains, Receptors, Serotonin, Spiperone