MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.
King BH., Brazell C., Dourish CT., Middlemiss DN.
The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked by the 5-HT1C antagonists mesulergine and metergoline but not by spiperone, ketanserin, or (-)-pindolol. The results suggest that MK-212 activates the 5-HT1C receptor subtype to increase ACTH.