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The 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), buspirone or TVXQ 7821 (ipsapirone) but not the 5-HT1B agonist RU 24969, attenuated the hyperphagic response to 8-OH-DPAT administered on the next day. Attenuation was still apparent on the fifth day after either 8-OH-DPAT or buspirone but not on the tenth day after 8-OH-DPAT administration. The ability of 8-OH-DPAT to reduce raphe 5-HIAA levels was also impaired by previous 8-OH-DPAT treatment. However, the 8-OH-DPAT or 5-methoxy-N,N-dimethyltryptamine-induced 5-HT syndromes were unaltered. The results indicate that a single pretreatment with 5-HT1A agonists rapidly desensitises 5-HT1A presynaptic receptor-mediated responses. This effect may mediate the antidepressant-like action of the drugs in an animal model of depression.

Type

Journal article

Journal

Eur J Pharmacol

Publication Date

12/06/1987

Volume

138

Pages

53 - 60

Keywords

8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Antidepressive Agents, Behavior, Animal, Brain Chemistry, Cerebral Cortex, Eating, Hydroxyindoleacetic Acid, Male, Methoxydimethyltryptamines, Raphe Nuclei, Rats, Rats, Inbred Strains, Receptors, Serotonin, Serotonin, Synapses, Tetrahydronaphthalenes