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Administration of 60 micrograms/kg s.c. of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), a dose previously shown to cause hyperphagia in satiated rats (but not to cause the 5-HT behavioural syndrome) decreased 5-HIAA and 5-HIAA/5-HT ratio in several brain regions, the most marked effects being in pons + medulla oblongata, a region containing 5-HT cell bodies and ascending 5-HT axons. Micro-infusion of 8-OH-DPAT (250 and 500 ng) into the dorsal or medial raphe nuclei significantly increased food intake and feeding duration but did not produce the 5-HT behavioural syndrome. Results suggest that 8-OH-DPAT induced hyperphagia is mediated via a agonist action on somatodendritic 5-HT autoreceptors.

Type

Journal article

Journal

Eur J Pharmacol

Publication Date

07/10/1986

Volume

129

Pages

347 - 352

Keywords

8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Brain, Eating, Feeding and Eating Disorders, Hydroxyindoleacetic Acid, Hyperphagia, Male, Naphthalenes, Rats, Rats, Inbred Strains, Receptors, Serotonin, Serotonin, Tetrahydronaphthalenes