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ET 495 (piribedil) produced significant hypodipsia in thirsty rats at 5 and 20 mg . kg-1, the effect being greater at the lower dose. At 5 mg . kg-1 ET 495 also induced a significant sedating effect, a characteristic of small doses of dopamine agonists. Both the hypodipsic and sedating effects of ET 495 were completely reversed by pretreatment with spiperone. The slight hypodipsia produced at 20 mg . kg-1 was accompanied by signs of low intensity behavioural stereotypy. The stereotypy, unlike the other behavioural effects of ET 495 treatment, was not antagonized by spiperone pretreatment.


Journal article



Publication Date





69 - 72


Animals, Butyrophenones, Dextroamphetamine, Drinking, Humans, Hypnotics and Sedatives, Male, Piperazines, Piribedil, Rats, Rats, Inbred Strains, Spiperone, Stereotyped Behavior