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This paper briefly reviews the role of the neurotransmitter dopamine (DA) in thirst and drinking behaviour. Electrolytic lesions of the lateral hypothalamus or 6-OHDA lesions of the nigro-striatal DA pathway produce aphaghia and adipsia. Similarly, DA receptor blockade inhibits drinking whereas the administration of DA or DA agonists can facilitate drinking. The involvement of DA in thirst is discussed with respect to the mediation of the motivational and motor responses associated with drinking behaviour.


Journal article


Prog Neuropsychopharmacol Biol Psychiatry

Publication Date





487 - 493


Animals, Brain, Corpus Striatum, Dopamine, Drinking, Eating, Haplorhini, Hypothalamic Area, Lateral, Limbic System, Mesencephalon, Neural Pathways, Receptors, Dopamine, Substantia Nigra, Synaptic Transmission, Thirst