Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The effects of beta-phenylethylamine (PEA) (6.25-50 mg kg-1) and of naloxone (1-10 mg kg-1), administered alone and in combination, were studied in the rat. Adult, male rats were individually tested in a novel enclosure over a 30 min period, after administration of drugs. Measures of total horizontal activity, ambulation and rearing activity were counted automatically on the basis of interruptions of photobeams. In addition, observational data were collected, using behavioural categories which have previously been used to characterize the behavioural stereotypy syndrome induced by phenylethylamine in large doses. The results showed that certain combinations of phenylethylamine and naloxone produced striking increases in total horizontal activity and ambulation scores, but not in vertical activity scores. Furthermore, naloxone antagonized hyperreactivity and splayed-hindlimb components of the stereotypy syndrome induced by phenylethylamine, but not the head-weaving component. The behavioural specificity of the potentiation of total horizontal activity and ambulation by phenylethylamine in combination with naloxone is emphasized, and the enhancement of activity is contrasted with previous reports of the effects of naloxone administered in conjunction with d-amphetamine.

Type

Journal article

Journal

Neuropharmacology

Publication Date

09/1984

Volume

23

Pages

1059 - 1064

Keywords

Amphetamine, Animals, Drug Synergism, Humans, Male, Motor Activity, Naloxone, Phenethylamines, Rats, Rats, Inbred Strains, Receptors, Opioid, Stereotyped Behavior