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A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.

Original publication

DOI

10.1039/c8cc01400k

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

17/07/2018

Volume

54

Pages

8120 - 8123

Keywords

Administration, Intranasal, Animals, Brain, Female, Fluorine Radioisotopes, Half-Life, Heterocyclic Compounds, 1-Ring, Male, Olfactory Bulb, Peptides, Cyclic, Positron-Emission Tomography, Radiopharmaceuticals, Rats, Wistar, Receptors, Oxytocin, Structure-Activity Relationship