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The present report describes extrapyramidal side effects (EPS) appearing after 32 months of exclusive treatment with clozapine at low dosages. This case evidences that long-term treatment with clozapine may be associated with EPS and suggests that, even if clozapine is considered the medication with the fewest EPS and it is often prescribed as an effective treatment for them, its use does not fully eliminate the risk of neurological side effects.

Original publication




Journal article


Riv Psichiatr

Publication Date





172 - 173


Adult, Antipsychotic Agents, Basal Ganglia Diseases, Clozapine, Drug Substitution, Humans, Hypokinesia, Male, Muscle Hypertonia, Psychotic Disorders, Risperidone, Thioridazine, Tremor