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The aim of the present study was to investigate P300 event-related potential components in euthymic bipolar disorder type I (BDI) and bipolar disorder type II (BDII) patients and matched controls. A total of 10 BDI patients, 10 BDII patients and 10 healthy individuals were enrolled in the study. Event-related potential data were collected according to a standard auditory 'oddball' paradigm. A significant groups effect in both the peak amplitude (P<0.001) and the mean amplitude (P<0.001) was observed; post-hoc comparisons showed that the peak and mean amplitudes of BDI and BDII patients were significantly lower than the peak and mean amplitudes of the healthy controls. The neurophysiological patterns found in the present study might at least partially reflect the presence of a mild selective cognitive impairment in euthymic BDI and BDII patients. From a clinical point of view, these evidences support the potential role of cognitive interventions in the treatment of BD.

Original publication

DOI

10.1097/WNR.0000000000000329

Type

Journal article

Journal

Neuroreport

Publication Date

04/03/2015

Volume

26

Pages

206 - 210

Keywords

Adult, Aged, Bipolar Disorder, Cerebral Cortex, Cognition Disorders, Electroencephalography, Event-Related Potentials, P300, Evoked Potentials, Auditory, Female, Humans, Male, Middle Aged