Human induced Pluripotent Stem Cell (hiPSC) models are a valuable new tool for research into neurodegenerative diseases. Neuroinflammation is now recognized as a key process in neurodegenerative disease and aging, and microglia are central players in this. A plethora of hiPSC-derived microglial models have been published recently to explore neuroinflammation, ranging from monoculture through to xenotransplantation. However, combining physiological relevance, reproducibility, and scalability into one model is still a challenge. We examine key features of the in vitro microglial environment, especially media composition, extracellular matrix, and co-culture, to identify areas for improvement in current hiPSC-microglia models.
Journal article
2020-01-01T00:00:00+00:00
11
3D scaffolds, co-culture, human, in vitro models, induced pluripotent stem cells, media composition, microglia, physiological relevance, Animals, Cell Culture Techniques, Cells, Cultured, Cellular Microenvironment, Coculture Techniques, Culture Media, Culture Media, Serum-Free, Heterografts, Humans, Induced Pluripotent Stem Cells, Inflammation, Mice, Microglia, Models, Biological, Neurodegenerative Diseases