Clinical trials & experimental medicine — Department of Psychiatry

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Groups within this theme

The Translational Neurostimulation Lab (TNSL team) work on understanding neurocognitive mechanisms of brain plasticity in health and neurological/psychiatric disorders. Recent work is focused on advancing non-invasive brain stimulation as a treatment for depression. Using an experimental medicine/cognitive neuroscience approach, we ask mechanistic questions aimed at understanding: How does stimulation work? Who does it work for? How can we make it work better?

Translational NeuroStimulation Laboratory

Using computer models of behaviour, we aim to better understand anxiety and depression, and to guide the development of novel treatments.

Computational Psychiatry

We undertake research across the translational spectrum, ranging from basis science studies, through to trials of new treatments and approaches for psychosis, right through to researching clinical services and their effectiveness. We work closely with the Oxfordshire Early Intervention in Psychosis Service in Oxford Health NHS FT. This service provides high quality, multi-discliplinary care for people experiencing first episode of psychosis and their families. We also lead the Early Intervention Psychosis network for the NHS in the South of England, providing the opportunity to speed up the translation of new research findings into routine clinical care. You can find out more about our current studies below.

Early Psychosis Research Group

We conduct research across the translational spectrum to understand how immune and metabolic processes contribute to the development and progression of severe mental illnesses, such as psychosis and schizophrenia.

Immuno-metabolism & Severe Mental Illness Group

People with mental illness have a markedly shorter life expectancy than the general population, largely because of preventable cardiometabolic disease. We are interested in understanding this not simply as a comorbidity, but as part of the biology of these conditions, from the early, at-risk stages through to chronic severe mental illness.

Metabolic Brain and Body

Our work focuses on preventing depression, promoting mental health and human flourishing - and resourcing people to meet the challenges of the 21st century.

University of Oxford Mindfulness and Psychological Science Research Centre

We are dedicated to testing and developing new ways of improving treatments for psychiatric disorders, and maintaining brain health during aging. A significant proportion of people suffering from disturbances of mood and memory, do not respond to the available medication, and so there is an urgency to supplement or provide an alternative to current therapies.

Neurobiology and Experimental Therapeutics

Understanding Psychosis Across Brain, Behaviour, & Treatment

OPERA (Oxford Psychosis: Research & Application)

We are an international multidisciplinary group of researchers, clinicians (both psychiatrists and psychologists), statisticians, methodologists and students who aim to improve the current treatment practice in the NHS and across the world, using innovative approaches from artificial intelligence and machine learning, to digital mental health and bioethics.

Oxford Precision Psychiatry Lab

We explore how the brain processes emotional information and how this is influenced by brain chemicals and medicines. This helps us to understand disorders such as depression and anxiety and to understand and contribute to the development of drug and psychological treatments.

Psychopharmacology and Emotion Research Laboratory (PERL)

Principal Investigators

Michael Browning

Professor of Computational Psychiatry

Philip Burnet

Professor of Neuroscience

Andrea Cipriani

Professor of Psychiatry

Philip Cowen

Professor of Psychopharmacology

Catherine Harmer

Associate Head of Department (People and Culture), Professor of Cognitive ...

John Geddes

Professor of Psychiatry

Belinda Lennox

Head of Department

Rachel Upthegrove

Professor of Psychiatry, Director NIHR Oxford Health Biomedical Research Centre

Jacinta O'Shea

Professor of Cognitive Neuroscience | Wellcome/Royal Society Sir Henry Dale ...

Vanessa Raymont

Associate Professor, R&D Director Oxford Health NHS Foundation Trust

Andrea Reinecke

Associate Professor