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Annabel Walsh

BSc (Hons), MRes, DPhil

Post-doctoral Research Assistant

Research Summary

University of Manchester - BSc (Hons) Neuroscience 

University College London - MRes Cognitive Neuroscience 

University of Oxford - DPhil Psychiatry

My main research interest is depression and the cognitive neuropsychological model of antidepressant response. Depression is characterised by two core diagnostic symptoms - low mood and a loss of reward know as anhedonia. 

Previous research indicates that serotonergic and/or noradrenergic antidepressants can remediate negative biases in emotional processing early in treatment, prior to mood improvement. However, such antidepressant treatment is clearly not sufficiently effective in all patients and tends not to treat the anhedonia. The effects on reward processing potentially relevant to the treatment of anhedonia are less clear but may be particularly affected by antidepressants with an effect on dopamine function. Therefore, my work currently focuses on the effects of the dopamine and noradrenaline reuptake inhibitor bupropion on behavioural and neural measures of both emotional and reward processing in depressed patients.

My work is supported by the department, J&J and the Oxford Health NHS Foundation Trust Biomedical Research Centre 

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