Elena M. Ribe

PhD

Senior Postdoctoral Research Scientist

My research interests focus around understanding the molecular mechanisms underlying Alzheimer´s disease (AD) pathological events. My experience centres in pre-clinical research: understanding basic mechanisms of disease to early drug discovery. I have generated one of the most informative mouse models of Alzheimer´s disease and neurodegeneration and I have tracked experience in the use of primary neuronal cultures to unravel the molecular mechanisms leading to neurotoxicity and associated pathology in the core of the amyloid pathway. Now at Oxford I´m using both these expertise to start a drug discovery programme covering a more translational approach.

Recent publications

Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links.
Journal article

Ribe EM. and Lovestone S., (2016), J Intern Med, 280, 430 - 442
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.
Journal article

Killick R. et al, (2014), Mol Psychiatry, 19, 88 - 98
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Journal article

Jean YY. et al, (2013), Biochem J, 455, 15 - 25
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.
Journal article

Pozueta J. et al, (2013), Nat Commun, 4
Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
Journal article

Ribe EM. et al, (2012), Biochem J, 444, 591 - 599

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