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Stem Cell Derived Neurosphere Assay

See paper for more information 

Lahiru Handunnetthi

Principal Investigator and Consultant Neurologist

Neuro-immune Interactions

Lahiru Handunnetthi aims to understand how inflammation and infections contribute to the development of psychiatric and neurological disease. He combines genomics methodology with stem cell derived model systems to better understand neuro-immune interactions and to identify therapeutic targets for neuroinflammatory disease.

Lahiru is involved in the functional characterisation of genetic risk alleles discovered through genome wide association studies. This involves gene editing techniques, induced pluripotent stem cell (IPSC) derived neuronal and glial model systems, as well as working with biological samples from patients.

Lahiru has a specific interest in understanding how the immune system contributes to psychosis. He is actively involved in discovering the roles that autoantibodies and viral infections play in psychosis.

Lahiru completed his DPhil at the Wellcome Centre for Human Genetics, University of Oxford. His work focused on understanding the interactions between genetic and environmental risk factors in neuroimmunological disorders. He studied medicine at the University of Cambridge and held an NIHR funded Clinical Lectureship in Neurology.

Key words:  Stem Cells, Neuroimmunology, Immunopsychiatry, Neuroinfectious diseases