Michael Clark
BSc (Hons), MSc, PhD
Research Fellow
- CJ Martin Biomedical Fellow
Numerous regions in our DNA influence how likely we are to develop various diseases, including brain disorders, cancer and heart disease. Unexpectedly, many of these DNA regions don't appear to contain any genes, making it difficult to work out how they trigger disease.
In my research I search for new genes currently 'hidden' in these disease-associated regions, with a particular focus on neuropsychiatric disorders such as schizophrenia and bipolar disorder. By determining what roles these new genes perform in our cells and what happens when they function incorrectly, my research aims to better understand the causes of human disease.
Recent publications
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Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain.
Journal article
Clark MB. et al, (2019), Mol Psychiatry
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Universal Alternative Splicing of Noncoding Exons.
Journal article
Deveson IW. et al, (2018), Cell Syst, 6, 245 - 255.e5
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Intergenic disease-associated regions are abundant in novel transcripts.
Journal article
Bartonicek N. et al, (2017), Genome biology, 18, 241 - 241
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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.
Journal article
Betts JA. et al, (2017), American Journal of Human Genetics, 101, 255 - 266
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RNAcentral: a comprehensive database of non-coding RNA sequences.
Journal article
The RNAcentral Consortium None., (2017), Nucleic Acids Research, 45, D128 - D134