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BSc (Hons), MSc, PhD
- CJ Martin Biomedical Fellow
Numerous regions in our DNA influence how likely we are to develop various diseases, including brain disorders, cancer and heart disease. Unexpectedly, many of these DNA regions don't appear to contain any genes, making it difficult to work out how they trigger disease.
In my research I search for new genes currently 'hidden' in these disease-associated regions, with a particular focus on neuropsychiatric disorders such as schizophrenia and bipolar disorder. By determining what roles these new genes perform in our cells and what happens when they function incorrectly, my research aims to better understand the causes of human disease.
RNAcentral: a comprehensive database of non-coding RNA sequences.
The RNAcentral Consortium None., (2017), Nucleic Acids Res, 45, D128 - D134
Improved definition of the mouse transcriptome via targeted RNA sequencing.
Bussotti G. et al, (2016), Genome Res, 26, 705 - 716
Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing.
Clark MB. et al, (2015), Nat Methods, 12, 339 - 342
Genome-wide discovery of human splicing branchpoints.
Mercer TR. et al, (2015), Genome Res, 25, 290 - 303
RNAcentral: an international database of ncRNA sequences.
RNAcentral Consortium None., (2015), Nucleic Acids Res, 43, D123 - D129