Michael Clark
BSc (Hons), MSc, PhD
Research Fellow
- CJ Martin Biomedical Fellow
Numerous regions in our DNA influence how likely we are to develop various diseases, including brain disorders, cancer and heart disease. Unexpectedly, many of these DNA regions don't appear to contain any genes, making it difficult to work out how they trigger disease.
In my research I search for new genes currently 'hidden' in these disease-associated regions, with a particular focus on neuropsychiatric disorders such as schizophrenia and bipolar disorder. By determining what roles these new genes perform in our cells and what happens when they function incorrectly, my research aims to better understand the causes of human disease.
Recent publications
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CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice.
Journal article
Vacante F. et al, (2021), Circ Res, 128, 1258 - 1275
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The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read differential expression analysis tools
Journal article
Dong X. et al, (2021), NAR Genomics and Bioinformatics, 3
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Multiomic analysis elucidates Complex I deficiency caused by a deep intronic variant in NDUFB10.
Journal article
Helman G. et al, (2020), Hum Mutat
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Nanopore direct RNA sequencing detects differential expression between human cell populations
Journal article
Gleeson J. et al, (2020), bioRxiv
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The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read tools
Journal article
Dong X. et al, (2020)