Michael Clark
BSc (Hons), MSc, PhD
Research Fellow
- CJ Martin Biomedical Fellow
Numerous regions in our DNA influence how likely we are to develop various diseases, including brain disorders, cancer and heart disease. Unexpectedly, many of these DNA regions don't appear to contain any genes, making it difficult to work out how they trigger disease.
In my research I search for new genes currently 'hidden' in these disease-associated regions, with a particular focus on neuropsychiatric disorders such as schizophrenia and bipolar disorder. By determining what roles these new genes perform in our cells and what happens when they function incorrectly, my research aims to better understand the causes of human disease.
Recent publications
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The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read tools
Journal article
Dong X. et al, (2020)
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Targeted RNA sequencing enhances gene expression profiling of ultra-low input samples.
Journal article
Curion F. et al, (2020), RNA Biol, 1 - 13
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RNA sequencing identifies a cryptic exon caused by a deep intronic variant in NDUFB10 resulting in isolated Complex I deficiency.
Journal article
Helman G. et al, (2020)
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Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain.
Journal article
Clark MB. et al, (2019), Mol Psychiatry
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Universal Alternative Splicing of Noncoding Exons.
Journal article
Deveson IW. et al, (2018), Cell Syst, 6, 245 - 255.e5