Dr Nisha Singh
Nisha Singh
BPharmacy, MSc & DPhil Pharmacology
Senior Postdoctoral Researcher in Psychopharmacology
Senior Postdoctoral Researcher in Psychopharmacology
I am a pharmacologist by training, with demonstrable experience in translation research, and a strong interest in drug repurposing in psychiatry. I have been an instrumental part of an academic team working on a potential, new lithium-like drug called ebselen, which we have taken from inception through to clinical evaluation.
Prior to this, I was a Research Fellow in Radiopharmacology at King’s College, London where I was developing and evaluating radiotracers for the GABA and glutamate neurotransmitter systems. This position provided me with the unique opportunity to gain an understanding in all aspects of PET imaging, from chemistry and physics in the laboratory, to clinical studies of new radiotracers evaluating brain function.
At present, I am further developing ebselen for treatment-resistant depression and other psychiatric conditions, as well as utilising imaging techniques, both PET and MRI, to evaluate its effects on the glutamatergic system.
Recent publications
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Evaluation of [13N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain.
Journal article
Egerton A. et al, (2020), EJNMMI Res, 10
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A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Journal article
Sharpley AL. et al, (2020), Psychopharmacology (Berl)
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Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Journal article
Singh N. et al, (2020), Eur J Pharmacol
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MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD
Journal article
Lin Z. et al, (2020)
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Radiolabeling of [11C]FPS-ZM1, a receptor for advanced glycation end products-targeting positron emission tomography radiotracer, using a [11C]CO2-to-[11C]CO chemical conversion.
Journal article
Luzi F. et al, (2020), Future Med Chem