From predisposition to illness: genetically sensitive intermediate pathways to mood disorders.
Duffy A.
The contemporary model of mood disorders proposes that multiple susceptibility genes interact with multiple other risk factors. However, the specific nature of the genetic vulnerability and the intermediate causal pathways are not known. In this edition of the Journal, Goodyer and colleagues report new findings suggesting genetic moderation of an association between elevated cortisol and depression in high-risk adolescents.